Melatonin's protective action against ischemic neuronal damage is associated with [PMID: 20544829] Laboratory literature summary: Melatonin's protective action against ischemic neuronal damage is associated with up-regulation of the MT2 melatonin receptor
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However, during clinical translation, the structural complexity of the human liver, the heterogeneity of disease microenvironments, and interspecies differences often lead to suboptimal performance of nanodrugs in human trials despite promising results in preclinical animal studies
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